Open AccessProgramming of the Hypothalamus-Pituitary-Adrenal Axis by Very Preterm Birth
Author(s) -
Martijn J.J. Finken,
Bibian van der Voorn,
Jonneke J. Hollanders,
Charlotte A. Ruys,
Marita de Waard,
Johannes B. van Goudoever,
Joost Rotteveel
Publication year - 2017
Publication title -
annals of nutrition and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.926
H-Index - 81
eISSN - 1421-9697
pISSN - 0250-6807
DOI - 10.1159/000456040
Subject(s) - endocrinology , medicine , hypothalamus , glucocorticoid , hypothalamic–pituitary–adrenal axis , adrenocorticotropic hormone , cortisone , corticotropin releasing hormone , hydrocortisone , hormone , basal (medicine) , insulin
Many very preterm (i.e., <32 weeks of gestation) newborns fail to mount an adequate adrenocortical response to stress or illness, termed relative adrenal insufficiency. Conversely, later in life these infants show features of increased glucocorticoid bioactivity, such as abdominal adiposity, insulin resistance, raised blood pressure, shorter stature and internalizing problem behavior.
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