Inflammasome Activation by ATP Enhances Citrobacter rodentium Clearance through ROS Generation | Zendy

Michael BordingJorgensen | Zendy; Misagh Alipour | Zendy; Eytan Wine | Zendy; Ghazal Danesh | Zendy

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Inflammasome Activation by ATP Enhances Citrobacter rodentium Clearance through ROS Generation

Author(s) -

Michael BordingJorgensen,

Misagh Alipour,

Eytan Wine,

Ghazal Danesh

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000455988

Subject(s) - inflammasome , reactive oxygen species , inflammation , phagocytosis , chemistry , nod , citrobacter rodentium , aim2 , lipopolysaccharide , microbiology and biotechnology , activator (genetics) , secretion , biology , receptor , immunology , biochemistry , gene

Nod-like receptor family, pyrin domain containing 3 (NLRP3) is an important cytosolic sensor of cellular stress and infection. Once activated, NLRP3 forms a multiprotein complex (inflammasome) that triggers the maturation and secretion of interleukin (IL)-1β and IL-18. We aimed to define the consequences of NLRP3 induction, utilizing exogenous adenosine triphosphate (ATP) as an inflammasome activator, to determine if inflammasome activation increases macrophage killing of Citrobacter rodentium and define mechanisms.

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