MiR-21 Regulates TNF-α-Induced CD40 Expression via the SIRT1-NF-κB Pathway in Renal Inner Medullary Collecting Duct Cells | Zendy

Qinqin Lin | Zendy; Yuanwen Geng | Zendy; Meng Zhao | Zendy; Shuaishuai Lin | Zendy; Qing Zhu | Zendy; Zhenjun Tian | Zendy

Open Access

MiR-21 Regulates TNF-α-Induced CD40 Expression via the SIRT1-NF-κB Pathway in Renal Inner Medullary Collecting Duct Cells

Author(s) -

Qinqin Lin,

Yuanwen Geng,

Meng Zhao,

Shuaishuai Lin,

Qing Zhu,

Zhenjun Tian

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000455981

Subject(s) - transfection , nf κb , inflammation , small interfering rna , chemistry , microrna , tumor necrosis factor alpha , cd40 , microbiology and biotechnology , blot , nfkb1 , signal transduction , cancer research , biology , endocrinology , transcription factor , in vitro , immunology , biochemistry , cytotoxic t cell , gene

Recent studies have indicated that microRNA-21 (miR-21) is involved in the inflammatory response in relation to renal disease. Sirtuin1 (SIRT1) exerts renoprotective properties by counteracting inflammation. The activation of CD40 triggers inflammation that participates in renal inflammation and injury. The relationship between miR-21, SIRT1 and CD40, however, remains elusive.

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