Hepatitis B Virus Core Antigen Stimulates IL-6 Expression via p38, ERK and NF-κB Pathways in Hepatocytes | Zendy

Zhi Chen | Zendy; Yang-Xia Li | Zendy; Haijing Fu | Zendy; Yanli Ren | Zendy; Ling Zou | Zendy; Shizhen Shen | Zendy; Ping Chen | Zendy; Ting Sun | Zendy; Chunhong Huang | Zendy

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Hepatitis B Virus Core Antigen Stimulates IL-6 Expression via p38, ERK and NF-κB Pathways in Hepatocytes

Author(s) -

Zhi Chen,

Yang-Xia Li,

Haijing Fu,

Yanli Ren,

Ling Zou,

Shizhen Shen,

Ping Chen,

Ting Sun,

Chunhong Huang

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000455954

Subject(s) - mapk/erk pathway , hepatitis b virus , antigen , p38 mitogen activated protein kinases , virology , virus , nf κb , immunology , signal transduction , biology , microbiology and biotechnology , chemistry

Hepatitis B virus (HBV) causes both acute and chronic liver injury. Viral proteins are involved in the pathological progress. Hepatitis B core antigen (HBcAg), a component of viral nucleocapsid, is not only essential for HBV lifecycle, but also exhibits strong immunogenicity. The cytoplasmic location of HBcAg in liver biopsy is associated with liver injury and inflammation, but the exact mechanisms remain to be elaborated.

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