Remote Ischaemic Preconditioning and Sevoflurane Postconditioning Synergistically Protect Rats from Myocardial Injury Induced by Ischemia and Reperfusion Partly via Inhibition TLR4/MyD88/NF-κB Signaling Pathway | Zendy

Jiru Zhang | Zendy; Jing Zhang | Zendy; Peng Yu | Zendy; Min Chen | Zendy; Qingfeng Peng | Zendy; ZhiQiang Wang | Zendy; Nan Dong | Zendy

Open Access

Remote Ischaemic Preconditioning and Sevoflurane Postconditioning Synergistically Protect Rats from Myocardial Injury Induced by Ischemia and Reperfusion Partly via Inhibition TLR4/MyD88/NF-κB Signaling Pathway

Author(s) -

Jiru Zhang,

Jing Zhang,

Peng Yu,

Min Chen,

Qingfeng Peng,

ZhiQiang Wang,

Nan Dong

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000455815

Subject(s) - sevoflurane , ischemia , reperfusion injury , tlr4 , medicine , pharmacology , myocardial reperfusion injury , cardiology , ischemic preconditioning , nf κb , chemistry , receptor , inflammation

A combination sevoflurane postconditioning (SPC) and remote ischemic preconditioning (RIPC) is proved effective in an ex vivo rat heart perfusion model. However, the combined effect of those two interventions is not tested in rat myocardial ischemia/reperfusion (I/R) model, and the underlying mechanisms remain to be elucidated. This study aimed to investigate the effect in vivo using a rat myocardial I/R model and illuminate the related mechanisms.

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