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Allogeneic Compact Bone-Derived Mesenchymal Stem Cell Transplantation Attenuates the Severity of Idiopathic Pneumonia Syndrome in a Murine Bone Marrow Transplantation Model
Author(s) -
Shu-Kai Qiao,
Hanyun Ren,
Yong-Jin Shi,
Wei Liu
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000453215
Subject(s) - medicine , transplantation , ccl5 , immunology , mesenchymal stem cell , c c chemokine receptor type 7 , bronchoalveolar lavage , foxp3 , hematopoietic stem cell transplantation , bone marrow , transplantation chimera , stem cell , lung , t cell , chemokine , il 2 receptor , inflammation , haematopoiesis , biology , pathology , chemokine receptor , immune system , hematopoietic cell , genetics
Idiopathic pneumonia syndrome (IPS) is a serious and life-threatening lung complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and currently no effective therapies exist. This study was designed to determine whether transplantation of allogeneic murine compact bone derived- mesenchymal stem cells (CB-MSCs) could prevent the development of IPS.

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