Role of MiR-215 in Hirschsprung's Disease Pathogenesis by Targeting SIGLEC-8 | Zendy

Lei Hao | Zendy; Hongxing Li | Zendy; Hua Xie | Zendy; Chunxia Du | Zendy; Yankai Xia | Zendy; Weibing Tang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Role of MiR-215 in Hirschsprung's Disease Pathogenesis by Targeting SIGLEC-8

Author(s) -

Lei Hao,

Hongxing Li,

Hua Xie,

Chunxia Du,

Yankai Xia,

Weibing Tang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000453214

Subject(s) - pathogenesis , gene isoform , biology , microrna , flow cytometry , siglec , reporter gene , hek 293 cells , microbiology and biotechnology , gene expression , gene , gene knockdown , western blot , motility , lectin , immunology , genetics

Hirschsprung's disease (HSCR), known as aganglionosis, is an infrequent congenital gut motility disorder characterized by absence of enteric neurons. In this study, we focus on the role of the intronic miR-215 and its host gene isoleucyl-tRNA synthetase 2 (IARS2) in the pathogenesis of HSCR.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research