Bufalin Inhibits hTERT Expression and Colorectal Cancer Cell Growth by Targeting CPSF4 | Zendy

Ningning Zhang | Zendy; Yunpeng Xie | Zendy; Yidi Tai | Zendy; Yingying Gao | Zendy; Wei Guo | Zendy; Wendan Yu | Zendy; Jia Li | Zendy; Feng Xu | Zendy; Jiaojiao Hao | Zendy; Yue Gao | Zendy; Xinrui Zhao | Zendy; Yina Liao | Zendy; Wei Jiang | Zendy; Ge Liu | Zendy; Wuguo Deng | Zendy; Xiaonan Cui | Zendy

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Bufalin Inhibits hTERT Expression and Colorectal Cancer Cell Growth by Targeting CPSF4

Author(s) -

Ningning Zhang,

Yunpeng Xie,

Yidi Tai,

Yingying Gao,

Wei Guo,

Wendan Yu,

Jia Li,

Feng Xu,

Jiaojiao Hao,

Yue Gao,

Xinrui Zhao,

Yina Liao,

Wei Jiang,

Ge Liu,

Wuguo Deng,

Xiaonan Cui

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000453206

Subject(s) - bufalin , telomerase reverse transcriptase , cancer research , apoptosis , cell growth , cancer , cancer cell , telomerase , chemistry , colorectal cancer , chromatin immunoprecipitation , biology , medicine , gene expression , biochemistry , promoter , gene

Bufalin can induce apoptosis in certain human cancer cell lines, but bufalin has not yet been thoroughly evaluated in colorectal cancer cells. Cleavage and polyadenylation specific factor 4 (CPSF4) and human telomerase reverse transcriptase (hTERT) play important roles in colorectal cancer growth. The aim of this study was to investigate the roles and interactions of bufalin, CPSF4 and hTERT and the effects of bufalin in human colorectal cancer.

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