Eryptosis as an Underlying Mechanism in Systemic Lupus Erythematosus-Related Anemia | Zendy

Peipei Jiang | Zendy; Maohong Bian | Zendy; Wenjuan Ma | Zendy; Chunqiu Liu | Zendy; Peng Yang | Zendy; Bangqiang Zhu | Zendy; Yuanhong Xu | Zendy; Meijuan Zheng | Zendy; Jinpin Qiao | Zendy; Zongwen Shuai | Zendy; Xueyong Zhou | Zendy; Dake Huang | Zendy

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Eryptosis as an Underlying Mechanism in Systemic Lupus Erythematosus-Related Anemia

Author(s) -

Peipei Jiang,

Maohong Bian,

Wenjuan Ma,

Chunqiu Liu,

Peng Yang,

Bangqiang Zhu,

Yuanhong Xu,

Meijuan Zheng,

Jinpin Qiao,

Zongwen Shuai,

Xueyong Zhou,

Dake Huang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000453191

Subject(s) - phosphatidylserine , oxidative stress , medicine , anemia , reactive oxygen species , hematocrit , endocrinology , flow cytometry , apoptosis , hemoglobin , immunology , pathophysiology , chemistry , biochemistry , phospholipid , membrane

The progression of systemic lupus erythematosus (SLE) leads to anemia in patients, adversely affecting prognosis. The diverse causes of anemia may include excessive eryptosis or premature suicidal erythrocyte death characterized by cell shrinkage and phosphatidylserine (PS) exposure on the cell surface. The present study explored if SLE enhances eryptosis and the underlying mechanisms.

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