MiR-520b/e Regulates Proliferation and Migration by Simultaneously Targeting EGFR in Gastric Cancer
Author(s) -
Shuang Li,
Haiyang Zhang,
Tao Ning,
Xinyi Wang,
Rui Liu,
Haiou Yang,
Yueting Han,
Ting Deng,
Likun Zhou,
Le Zhang,
Ming Bai,
Xia Wang,
Shaohua Ge,
Guoguang Ying,
Yi Ba
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000453183
Subject(s) - gene silencing , microrna , cell growth , angiogenesis , cancer research , epidermal growth factor receptor , carcinogenesis , western blot , suppressor , cancer , cell culture , biology , chemistry , gene , biochemistry , genetics
MicroRNAs (miRNAs) have been demonstrated to play a crucial role in tumorigenesis. Previous studies have shown that miR-520b/e acts as a tumor suppressor in several tumors. Other studies indicated that epidermal growth factor receptor (EGFR) is highly expressed in many tumors, and involved in the development of tumors, such as cell proliferation, migration, angiogenesis and apoptosis. However, the correlation of miRNAs and EGFR in gastric cancer (GC) has not been adequately investigated. Our aim was to explore the relationship.
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