Streptozotocin Inhibits Electrophysiological Determinants of Excitatory and Inhibitory Synaptic Transmission in CA1 Pyramidal Neurons of Rat Hippocampal Slices: Reduction of These Effects by Edaravone | Zendy

Ting Ju | Zendy; Yuru Li | Zendy; Xiaoran Wang | Zendy; Lifeng Xiao | Zendy; Li Jiang | Zendy; Shanshan Zhou | Zendy; Meimei Yang | Zendy; Tingting Zhao | Zendy; Lina Sun | Zendy; Tingjiao Liu | Zendy; Jinghan Lin | Zendy; Yi Xu | Zendy; Liming Zhang | Zendy

Open Access

Streptozotocin Inhibits Electrophysiological Determinants of Excitatory and Inhibitory Synaptic Transmission in CA1 Pyramidal Neurons of Rat Hippocampal Slices: Reduction of These Effects by Edaravone

Author(s) -

Ting Ju,

Yuru Li,

Xiaoran Wang,

Lifeng Xiao,

Li Jiang,

Shanshan Zhou,

Meimei Yang,

Tingting Zhao,

Lina Sun,

Tingjiao Liu,

Jinghan Lin,

Yi Xu,

Liming Zhang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000453181

Subject(s) - excitatory postsynaptic potential , postsynaptic current , inhibitory postsynaptic potential , neuroscience , electrophysiology , hippocampal formation , postsynaptic potential , neurotransmission , streptozotocin , chemistry , pharmacology , medicine , biology , diabetes mellitus , endocrinology , receptor , biochemistry

Streptozotocin (STZ) has served as an agent to generate an Alzheimer's disease (AD) model in rats, while edaravone (EDA), a novel free radical scavenger, has recently emerged as an effective treatment for use in vivo and vitro AD models. However, to date, these beneficial effects of EDA have only been clearly demonstrated within STZ-induced animal models of AD and in cell models of AD. A better understanding of the mechanisms of EDA may provide the opportunity for their clinical application in the treatment of AD. Therefore, the purpose of this study was to investigate the underlying mechanisms of STZ and EDA as assessed upon electrophysiological alterations in CA1 pyramidal neurons of rat hippocampal slices.

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