Up-Regulation of Excitatory Amino Acid Transporters EAAT3 and EAAT4 by Lithium Sensitive Glycogen Synthase Kinase GSK3ß | Zendy

Abeer Abousaab | Zendy; Florian Läng | Zendy

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Up-Regulation of Excitatory Amino Acid Transporters EAAT3 and EAAT4 by Lithium Sensitive Glycogen Synthase Kinase GSK3ß

Author(s) -

Abeer Abousaab,

Florian Läng

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000453179

Subject(s) - gsk 3 , microbiology and biotechnology , glycogen synthase , lithium (medication) , excitatory postsynaptic potential , kinase , glutamate receptor , xenopus , chemistry , gsk3b , phosphorylation , biochemistry , biology , receptor , endocrinology , gene

Cellular uptake of glutamate by the excitatory amino-acid transporters (EAATs) decreases excitation and thus participates in the regulation of neuroexcitability. Kinases impacting on neuronal function include Lithium-sensitive glycogen synthase kinase GSK3ß. The present study thus explored whether the activities of EAAT3 and/or EAAT4 isoforms are sensitive to GSK3ß.

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