A Feed-Forward Regulatory Loop between HuR and the Long Noncoding RNA HOTAIR Promotes Head and Neck Squamous Cell Carcinoma Progression and Metastasis | Zendy

Cheng-Zhi Xu | Zendy; Chenyan Jiang | Zendy; Qingwei Wu | Zendy; Liu Liu | Zendy; Xiaojun Yan | Zendy; Runjie Shi | Zendy

Open Access

A Feed-Forward Regulatory Loop between HuR and the Long Noncoding RNA HOTAIR Promotes Head and Neck Squamous Cell Carcinoma Progression and Metastasis

Author(s) -

Cheng-Zhi Xu,

Chenyan Jiang,

Qingwei Wu,

Liu Liu,

Xiaojun Yan,

Runjie Shi

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000453160

Subject(s) - hotair , gene knockdown , head and neck squamous cell carcinoma , hox gene , cancer research , biology , microrna , long non coding rna , viability assay , cell , cell culture , gene expression , rna , cancer , gene , genetics , head and neck cancer

The lncRNA Homeobox (HOX) transcript antisense RNA (HOTAIR) is overexpressed in numerous cancers. HuR is also overexpressed during tumourigenesis and is abnormally present within the cytoplasm, where it binds to AU-rich elements in the 3'UTRs of target mRNA and post-transcriptionally regulates the expression of its target genes. However, whether HOTAIR is regulated and the mechanisms by which it affects head and neck squamous cell carcinoma (HNSCC) are not well understood.

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