Pentraxin 3 Activates JNK Signaling and Regulates the Epithelial-To-Mesenchymal Transition in Renal Fibrosis | Zendy

TungWei Hung | Zendy; JenPi Tsai | Zendy; ShinHuey Lin | Zendy; Chien-Hsing Lee | Zendy; YiHsien Hsieh | Zendy; HorngRong Chang | Zendy

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Pentraxin 3 Activates JNK Signaling and Regulates the Epithelial-To-Mesenchymal Transition in Renal Fibrosis

Author(s) -

TungWei Hung,

JenPi Tsai,

ShinHuey Lin,

Chien-Hsing Lee,

YiHsien Hsieh,

HorngRong Chang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000453159

Subject(s) - ptx3 , epithelial–mesenchymal transition , vimentin , cell migration , downregulation and upregulation , fibrosis , cancer research , cell , chemistry , microbiology and biotechnology , biology , medicine , inflammation , immunology , immunohistochemistry , biochemistry , gene

Tubulointerstitial fibrosis can lead to end-stage renal disease. Pentraxin 3 (PTX3) is an acute phase protein produced by resident and innate immunity cells. We investigated the effect of PTX3 on cultured human proximal tubular epithelial (HK-2) cells and a rat unilateral ureteral obstruction (UUO) model of renal fibrosis.

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