Anti-Cancer Effect of Cap-Translation Inhibitor 4EGI-1 in Human Glioma U87 Cells: Involvement of Mitochondrial Dysfunction and ER Stress | Zendy

Ming Wu | Zendy; Chi Zhang | Zendy; Xuejun Li | Zendy; Qing Liu | Zendy; Siyi Wanggou | Zendy

Open Access

Anti-Cancer Effect of Cap-Translation Inhibitor 4EGI-1 in Human Glioma U87 Cells: Involvement of Mitochondrial Dysfunction and ER Stress

Author(s) -

Ming Wu,

Chi Zhang,

Xuejun Li,

Qing Liu,

Siyi Wanggou

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000453158

Subject(s) - unfolded protein response , apoptosis , microbiology and biotechnology , viability assay , biology , cancer cell , tunel assay , flow cytometry , programmed cell death , gene knockdown , western blot , cancer research , chemistry , cancer , biochemistry , genetics , gene

Cancer cells are frequently addicted to deregulated oncogenic protein translation that usually arises as a consequence of increased signaling flux from eIF4F activation. The small molecule 4EG-I, a potent inhibitor of translation initiation through disrupting eIF4E/eIF4G interaction, has been shown to exert anticancer effects in animal models of human cancers.

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