CXCL12 Regulates the Cholinergic Locus and CHT1 Through Akt Signaling Pathway | Zendy

Jing Yan | Zendy; Wenhui Zhao | Zendy; Meixia Guo | Zendy; Xuefei Han | Zendy; Zhiwei Feng | Zendy

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CXCL12 Regulates the Cholinergic Locus and CHT1 Through Akt Signaling Pathway

Author(s) -

Jing Yan,

Wenhui Zhao,

Meixia Guo,

Xuefei Han,

Zhiwei Feng

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000453155

Subject(s) - choline acetyltransferase , cholinergic , vesicular acetylcholine transporter , protein kinase b , acetylcholine , cholinergic neuron , biology , microbiology and biotechnology , signal transduction , chemistry , endocrinology , medicine

CXCL12 is pivotal for cholinergic neurons, and it induces the expressions of several genes that are essential for synthesis and storage of acetylcholine(ACh), specifically choline acetyltransferase, vesicular ACh transporter (VAChT), and choline transporter. The present study explored the impact of pharmacological Akt inhibition upon cholinergic gene expression.

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