Lipotoxic Palmitate Impairs the Rate of β-Oxidation and Citric Acid Cycle Flux in Rat Neonatal Cardiomyocytes | Zendy

Taha Haffar | Zendy; Ali Akoumi | Zendy; Nicolas Bousette | Zendy

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Lipotoxic Palmitate Impairs the Rate of β-Oxidation and Citric Acid Cycle Flux in Rat Neonatal Cardiomyocytes

Author(s) -

Taha Haffar,

Ali Akoumi,

Nicolas Bousette

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000453154

Subject(s) - flux (metallurgy) , chemistry , citric acid , citric acid cycle , microbiology and biotechnology , medicine , endocrinology , palmitic acid , biochemistry , biology , metabolism , fatty acid , organic chemistry

Diabetic hearts exhibit intracellular lipid accumulation. This suggests that the degree of fatty acid oxidation (FAO) in these hearts is insufficient to handle the elevated lipid uptake. We previously showed that palmitate impaired the rate of FAO in primary rat neonatal cardiomyocytes. Here we were interested in characterizing the site of FAO impairment induced by palmitate since it may shed light on the metabolic dysfunction that leads to lipid accumulation in diabetic hearts.

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