Smad3-mSin3A-HDAC1 Complex is Required for TGF-β1-Induced Transcriptional Inhibition of PPARγ in Mouse Cardiac Fibroblasts | Zendy

Kaizheng Gong | Zendy; Mingxing Chen | Zendy; Rujun Li | Zendy; Yanghong He | Zendy; Huajiang Zhu | Zendy; Dan Yao | Zendy; Suzanne Oparil | Zendy; Zhengang Zhang | Zendy

Open Access

Smad3-mSin3A-HDAC1 Complex is Required for TGF-β1-Induced Transcriptional Inhibition of PPARγ in Mouse Cardiac Fibroblasts

Author(s) -

Kaizheng Gong,

Mingxing Chen,

Rujun Li,

Yanghong He,

Huajiang Zhu,

Dan Yao,

Suzanne Oparil,

Zhengang Zhang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000453149

Subject(s) - chromatin immunoprecipitation , microbiology and biotechnology , transfection , transcription factor , peroxisome proliferator activated receptor , biology , smad , promoter , hdac1 , transcription (linguistics) , gene silencing , transcriptional regulation , luciferase , reporter gene , signal transduction , gene expression , gene , histone , biochemistry , histone deacetylase , linguistics , philosophy

We have recently demonstrated that activated transforming growth factor-β (TGF-β) signaling suppresses myocardial peroxisome proliferator-activated receptor γ (PPARγ) expression in the pressure overloaded heart. In this study, we aim to further define the molecular mechanisms that underlie TGF-β-induced PPARγ transcriptional inhibition.

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