Necroptosis Induced by Ad-HGF Activates Endogenous C-Kit+ Cardiac Stem Cells and Promotes Cardiomyocyte Proliferation and Angiogenesis in the Infarcted Aged Heart | Zendy

Jia Liu | Zendy; Peng Wu | Zendy; Hao Wang | Zendy; Yunle Wang | Zendy; Yingqiang Du | Zendy; Weili Cheng | Zendy; Zhihui Xu | Zendy; Ningtian Zhou | Zendy; Liansheng Wang | Zendy; Zhijian Yang | Zendy

Open Access

Necroptosis Induced by Ad-HGF Activates Endogenous C-Kit+ Cardiac Stem Cells and Promotes Cardiomyocyte Proliferation and Angiogenesis in the Infarcted Aged Heart

Author(s) -

Jia Liu,

Peng Wu,

Hao Wang,

Yunle Wang,

Yingqiang Du,

Weili Cheng,

Zhihui Xu,

Ningtian Zhou,

Liansheng Wang,

Zhijian Yang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000453144

Subject(s) - angiogenesis , necroptosis , stem cell , endogeny , cancer research , microbiology and biotechnology , medicine , biology , programmed cell death , apoptosis , biochemistry

The discovery of c-kit+ cardiac stem cells (CSCs) provided us with new therapeutic targets to repair the damaged heart. However, the precise mechanisms regulating CSC proliferation and differentiation in the aged heart remained elusive. Necroptosis, a type of regulated cell death, has recently been shown to occur following myocardial infarction (MI); however, its effect on c-kit+ CSCs remains unknown. We investigated the effects of hepatocyte growth factor (HGF) and necroptosis on the proliferation and differentiation of endogenous c-kit+ CSCs in aged rat hearts following MI.

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