The Pathogenesis of Alcohol-Induced Airflow Limitation in Acetaldehyde Dehydrogenase 2-Deficient Mice | Zendy

Terufumi Shimoda | Zendy; Yasushi Obase | Zendy; Hiroto Matsuse | Zendy; Sadahiro Asai | Zendy; Tomoaki Iwanaga | Zendy

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The Pathogenesis of Alcohol-Induced Airflow Limitation in Acetaldehyde Dehydrogenase 2-Deficient Mice

Author(s) -

Terufumi Shimoda,

Yasushi Obase,

Hiroto Matsuse,

Sadahiro Asai,

Tomoaki Iwanaga

Publication year - 2016

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000452709

Subject(s) - aldh2 , acetaldehyde , pathogenesis , aldehyde dehydrogenase , ethanol , histamine , endocrinology , alcohol dehydrogenase , medicine , alcohol , lactate dehydrogenase , chemistry , immunology , biochemistry , enzyme

In Japanese patients, alcohol-induced asthma is attributed to elevated plasma concentrations of acetaldehyde following alcohol consumption because of an acetaldehyde dehydrogenase 2 gene (ALDH2) polymorphism. The resulting increase in plasma histamine concentrations seems to trigger the onset of asthma symptoms. However, the specific pathogenic mechanism underlying this response remains unclear. ALDH2-deficient mice were therefore generated to investigate the pathogenesis of alcohol-induced asthma.

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