Periodontal Pathogens in the Etiology of Pancreatic Cancer | Zendy

Mesut Öğrendik | Zendy

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Periodontal Pathogens in the Etiology of Pancreatic Cancer

Author(s) -

Mesut Öğrendik

Publication year - 2016

Publication title -

gastrointestinal tumors

Language(s) - English

Resource type - Journals

eISSN - 2296-3766

pISSN - 2296-3774

DOI - 10.1159/000452708

Subject(s) - pancreatic cancer , porphyromonas gingivalis , tannerella forsythia , cancer , treponema denticola , pancreatitis , medicine , chronic periodontitis , periodontitis , immunology , cancer research , pathology , honeysuckle , alternative medicine , traditional chinese medicine

Pancreatic cancer is the fourth leading cause of cancer-related deaths worldwide. Chronic pancreatitis is frequently observed in patients with pancreatic cancer, and a significant relationship between orodigestive cancer-related deaths and chronic periodontitis has been detected. Porphyromonas gingivalis , Tannerella forsythia , and Treponema denticola , collectively called the Red complex, are the major pathogens responsible for chronic periodontitis and secrete peptidylarginine deiminase. Anti- P. gingivalis antibodies titers are higher in pancreatic cancer patients than in healthy subjects.

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