Stimulation of Erythrocyte Cell Membrane Scrambling by Quinine | Zendy

Morena Mischitelli | Zendy; Mohamed Jèmaà | Zendy; Mustafa Almasry | Zendy; Caterina Faggio | Zendy; Florian Läng | Zendy

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Stimulation of Erythrocyte Cell Membrane Scrambling by Quinine

Author(s) -

Morena Mischitelli,

Mohamed Jèmaà,

Mustafa Almasry,

Caterina Faggio,

Florian Läng

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000452578

Subject(s) - phosphatidylserine , ceramide , oxidative stress , quinine , annexin a5 , annexin , apoptosis , chemistry , microbiology and biotechnology , stimulation , biology , biochemistry , biophysics , endocrinology , phospholipid , membrane , immunology , malaria

The analkaloid drug quinine is utilized mainly for the chemoprophylaxis of malaria. The multiple side effects of quinine include hemolytic anemia and hemolytic uremic syndrome, disorders involving suicidal erythrocyte death or eryptosis, which is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Signaling contributing to stimulation of eryptosis include increase of cytosolic Ca2+ activity ([Ca2+]i), oxidative stress, ceramide and D4476 sensitive casein kinase. The present study explored the putative effect of quinine on eryptosis and elucidated cellular mechanisms involved.

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