High Uric Acid Activates the ROS-AMPK Pathway, Impairs CD68 Expression and Inhibits OxLDL-Induced Foam-Cell Formation in a Human Monocytic Cell Line, THP-1 | Zendy

Chaohuan Luo | Zendy; Xueke Lian | Zendy; Liangli Hong | Zendy; Jingfang Zou | Zendy; Zhi Li | Zendy; Yuzhang Zhu | Zendy; Tianliang Huang | Zendy; Yongneng Zhang | Zendy; Yaqiu Hu | Zendy; Huier Yuan | Zendy; Tengfei Wen | Zendy; Wanling Zhuang | Zendy; Bozhi Cai | Zendy; Xin Zhang | Zendy; Ichiro Hisatome | Zendy; Tetsuya Yamamoto | Zendy; Jiexiong Huang | Zendy; Jidong Cheng | Zendy

Open Access

High Uric Acid Activates the ROS-AMPK Pathway, Impairs CD68 Expression and Inhibits OxLDL-Induced Foam-Cell Formation in a Human Monocytic Cell Line, THP-1

Author(s) -

Chaohuan Luo,

Xueke Lian,

Liangli Hong,

Jingfang Zou,

Zhi Li,

Yuzhang Zhu,

Tianliang Huang,

Yongneng Zhang,

Yaqiu Hu,

Huier Yuan,

Tengfei Wen,

Wanling Zhuang,

Bozhi Cai,

Xin Zhang,

Ichiro Hisatome,

Tetsuya Yamamoto,

Jiexiong Huang,

Jidong Cheng

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000452567

Subject(s) - thp1 cell line , ampk , foam cell , chemistry , oxidative stress , cd14 , cell culture , monocyte , reactive oxygen species , endocrinology , medicine , microbiology and biotechnology , macrophage , protein kinase a , biology , flow cytometry , biochemistry , kinase , genetics , in vitro

Hyperuricemia is part of the metabolic-syndrome cluster of abdominal obesity, impaired glucose tolerance, insulin resistance, dyslipidemia, and hypertension. Monocytes/macrophages are critical in the development of metabolic syndrome, including gout, obesity and atherosclerosis. However, how high uric acid (HUA) exposure affects monocyte/macrophage function remains unclear. In this study, we investigated the molecular mechanism of HUA exposure in monocytes/macrophages and its impact on oxidized low-density lipoprotein (oxLDL)-induced foam-cell formation in a human monocytic cell line, THP-1.

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