MiR-146a Regulates Inflammatory Infiltration by Macrophages in Polymyositis/Dermatomyositis by Targeting TRAF6 and Affecting IL-17/ICAM-1 Pathway | Zendy

Yuanqin Yin | Zendy; Fei Li | Zendy; Jing Shi | Zendy; SongLin Li | Zendy; Jingjing Cai | Zendy; Youhong Jiang | Zendy

Open Access

MiR-146a Regulates Inflammatory Infiltration by Macrophages in Polymyositis/Dermatomyositis by Targeting TRAF6 and Affecting IL-17/ICAM-1 Pathway

Author(s) -

Yuanqin Yin,

Fei Li,

Jing Shi,

SongLin Li,

Jingjing Cai,

Youhong Jiang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000452563

Subject(s) - polymyositis , dermatomyositis , icam 1 , infiltration (hvac) , medicine , inflammation , cancer research , immunology , pathology , cell adhesion molecule , materials science , composite material

The primary objective of this study was to investigate the role of miR-146a in inducing the inflammatory infiltration of macrophages in polymyositis/dermatomyositis (PM/DM) through targeting TNF receptor associated factor 6 (TRAF6), which may further down-regulate the Interleukin-17 (IL-17)/Intercellular Adhesion Molecule 1 (ICAM-1) pathway.

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