Metformin Protects Neurons against Oxygen-Glucose Deprivation/Reoxygenation -Induced Injury by Down-Regulating MAD2B | Zendy

Xianfang Meng | Zendy; Guangpin Chu | Zendy; Zhihua Yang | Zendy; Ping Qiu | Zendy; Yue Hu | Zendy; Xiaohe Chen | Zendy; Wenpeng Peng | Zendy; Chen Ye | Zendy; Fang-Fang He | Zendy; Chun Zhang | Zendy

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Metformin Protects Neurons against Oxygen-Glucose Deprivation/Reoxygenation -Induced Injury by Down-Regulating MAD2B

Author(s) -

Xianfang Meng,

Guangpin Chu,

Zhihua Yang,

Ping Qiu,

Yue Hu,

Xiaohe Chen,

Wenpeng Peng,

Chen Ye,

Fang-Fang He,

Chun Zhang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000452562

Subject(s) - neuroprotection , metformin , viability assay , reactive oxygen species , pharmacology , neurotoxicity , lactate dehydrogenase , biology , apoptosis , microbiology and biotechnology , chemistry , endocrinology , medicine , biochemistry , insulin , toxicity , enzyme

Metformin, the common medication for type II diabetes, has protective effects on cerebral ischemia. However, the molecular mechanisms are far from clear. Mitotic arrest deficient 2-like protein 2 (MAD2B), an inhibitor of the anaphase-promoting complex (APC), is widely expressed in hippocampal and cortical neurons and plays an important role in mediating high glucose-induced neurotoxicity. The present study investigated whether metformin modifies the expression of MAD2B and to exert its neuroprotective effects in primary cultured cortical neurons during oxygen-glucose deprivation/reoxygenation (OGD/R), a widely used in vitro model of ischemia/reperfusion.

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