Pamidronate Attenuates Oxidative Stress and Energetic Metabolism Changes but Worsens Functional Outcomes in Acute Doxorubicin-Induced Cardiotoxicity in Rats | Zendy

Paula Bernardo de Carvalho | Zendy; Andréa de Freitas Gonçalves | Zendy; Patricia Alegre | Zendy; Paula S. Azevedo | Zendy; Meliza Goi Roscani | Zendy; Carolina Marabesi Bergamasco | Zendy; Pamela Modesto | Zendy; Ana Angélica Henrique Fernandes | Zendy; Marcos Ferreira Minicucci | Zendy; Sérgio Alberto Rupp de Paiva | Zendy; Leonardo Antonio | Zendy; Leonardo A. M. Zornoff | Zendy; Bertha Furlan Polegato | Zendy

Open Access

Pamidronate Attenuates Oxidative Stress and Energetic Metabolism Changes but Worsens Functional Outcomes in Acute Doxorubicin-Induced Cardiotoxicity in Rats

Author(s) -

Paula Bernardo de Carvalho,

Andréa de Freitas Gonçalves,

Patricia Alegre,

Paula S. Azevedo,

Meliza Goi Roscani,

Carolina Marabesi Bergamasco,

Pamela Modesto,

Ana Angélica Henrique Fernandes,

Marcos Ferreira Minicucci,

Sérgio Alberto Rupp de Paiva,

Leonardo Antonio,

Leonardo A. M. Zornoff,

Bertha Furlan Polegato

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000452558

Subject(s) - cardiotoxicity , doxorubicin , medicine , oxidative stress , anthracycline , endocrinology , pharmacology , ejection fraction , heart failure , cardiac function curve , chemotherapy , cancer , breast cancer

Cardiotoxicity is the major side effect of doxorubicin. As mechanisms that are involved in cardiotoxicity are ambiguous, new methods for attenuating cardiotoxicity are needed. Recent studies have shown that bisphosphonates can decrease oxidative stress. Therefore, the objective of this study was to evaluate the effect of pamidronate on preventing acute doxorubicin-induced cardiotoxicity.

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