Hedgehog Signaling is Associated with Liver Response to Fractionated Irradiation in Mice | Zendy

Ji-Eun Kim | Zendy; Sihyung Wang | Zendy; Jeongeun Hyun | Zendy; Cynthia D. Guy | Zendy; Youngmi Jung | Zendy

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Hedgehog Signaling is Associated with Liver Response to Fractionated Irradiation in Mice

Author(s) -

Ji-Eun Kim,

Sihyung Wang,

Jeongeun Hyun,

Cynthia D. Guy,

Youngmi Jung

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000452543

Subject(s) - hedgehog , hedgehog signaling pathway , cancer research , liver injury , liver cancer , fibrosis , medicine , patched , apoptosis , endocrinology , chemistry , biology , hepatocellular carcinoma , signal transduction , microbiology and biotechnology , biochemistry

Radiation-induced liver disease (RILD) is a major obstacle in treating liver cancer; however, the mechanisms underlying RILD development remain unclear. Hedgehog (Hh) orchestrates liver response to injury. Herein, we investigated the liver response with Hh to fractionated irradiation (FI) using a small murine model for RILD.

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