Tanshinone II A Attenuates TNF-α-Induced Expression of VCAM-1 and ICAM-1 in Endothelial Progenitor Cells by Blocking Activation of NF-κB | Zendy

Jinxiu Yang | Zendy; Yanyun Pan | Zendy; Junhua Ge | Zendy; Bin Chen | Zendy; Wei Mao | Zendy; Yuangang Qiu | Zendy; Xingxiang Wang | Zendy

Open Access

Tanshinone II A Attenuates TNF-α-Induced Expression of VCAM-1 and ICAM-1 in Endothelial Progenitor Cells by Blocking Activation of NF-κB

Author(s) -

Jinxiu Yang,

Yanyun Pan,

Junhua Ge,

Bin Chen,

Wei Mao,

Yuangang Qiu,

Xingxiang Wang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000452537

Subject(s) - vcam 1 , tumor necrosis factor alpha , cell adhesion molecule , chemistry , cell adhesion , icam 1 , microbiology and biotechnology , nf κb , iκb kinase , intercellular adhesion molecule 1 , progenitor cell , adhesion , signal transduction , phosphorylation , cancer research , immunology , biology , biochemistry , stem cell , organic chemistry

Tanshinone IIA (Tan IIA) is effective in the treatment of inflammation and atherosclerosis. The adhesion of inflammatory cells to vascular endothelium plays important role in atherogenic processes. This study examined the effects of Tan IIA on expression of adhesion molecules in tumor necrosis factor-α (TNF-α)-induced endothelial progenitor cells (EPCs).

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