Parthenolide Induces Reactive Oxygen Species-Mediated Autophagic Cell Death in Human Osteosarcoma Cells | Zendy

Yang Chen | Zendy; Qing Yang | Zendy; QingJie Kong | Zendy; Wen Yuan | Zendy; Yue-Ping Ou Yang | Zendy

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Parthenolide Induces Reactive Oxygen Species-Mediated Autophagic Cell Death in Human Osteosarcoma Cells

Author(s) -

Yang Chen,

Qing Yang,

QingJie Kong,

Wen Yuan,

Yue-Ping Ou Yang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000452532

Subject(s) - parthenolide , autophagy , apoptosis , programmed cell death , cancer cell , viability assay , mitophagy , cancer research , annexin , osteosarcoma , reactive oxygen species , chemistry , biology , microbiology and biotechnology , cancer , biochemistry , genetics

Osteosarcoma is a devastating tumor of bone, primarily affecting adolescents. Parthenolide, a naturally occurring small molecule that interferes with NF-κB signaling, has recently attracted considerable attention because of its pharmacological action involving anti-cancer effects. However, the mechanism of the cytotoxic effect exerted by parthenolide on tumor cells is not clearly defined today.

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