Cerebral Mast Cells Participate In Postoperative Cognitive Dysfunction by Promoting Astrocyte Activation | Zendy

Xiang Zhang | Zendy; Hao Yao | Zendy; Qingqing Qian | Zendy; Nana Li | Zendy; Wenjie Jin | Zendy; Yanning Qian | Zendy

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Cerebral Mast Cells Participate In Postoperative Cognitive Dysfunction by Promoting Astrocyte Activation

Author(s) -

Xiang Zhang,

Hao Yao,

Qingqing Qian,

Nana Li,

Wenjie Jin,

Yanning Qian

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000452528

Subject(s) - neuroinflammation , astrocyte , postoperative cognitive dysfunction , medicine , microglia , mast cell , pharmacology , neuroscience , anesthesia , inflammation , central nervous system , immunology , psychology , cognition

Astrocytes, the major glial cell type that has been increasingly recognized as contributing to neuroinflammation, are critical in the occurrence and development of postoperative cognitive dysfunction (POCD). Although emerging evidence showed that brain mast cells (MCs) are the "first responders" in neuroinflammation, little is known about the functional communication between MCs and astrocytes.

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