Inhibition of STAT Pathway Impairs Anti-Hepatitis C Virus Effect of Interferon Alpha | Zendy

LanJuan Zhao | Zendy; Sheng-Fei He | Zendy; Yuan Liu | Zendy; Ping Zhao | Zendy; Zhongqi Bian | Zendy; Zhongtian Qi | Zendy

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Inhibition of STAT Pathway Impairs Anti-Hepatitis C Virus Effect of Interferon Alpha

Author(s) -

LanJuan Zhao,

Sheng-Fei He,

Yuan Liu,

Ping Zhao,

Zhongqi Bian,

Zhongtian Qi

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000452526

Subject(s) - stat2 , stat1 , stat protein , stat , interferon , phosphorylation , jak stat signaling pathway , biology , virology , stat3 , hepatitis c virus , signal transduction , alpha interferon , interferon stimulated gene , cancer research , virus , immunology , innate immune system , microbiology and biotechnology , immune system , receptor tyrosine kinase

Signal transducer and activator of transcription (STAT) pathway plays an important role in antiviral efficacy of interferon alpha (IFN-α). IFN-α is the main therapeutic against hepatitis C virus (HCV) infection. We explored effects of IFN-α on HCV replication and antiviral gene expression by targeting STAT.

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