Knockdown of Radixin Suppresses Gastric Cancer Metastasis In Vitro by Up-Regulation of E-Cadherin via NF-κB/Snail Pathway | Zendy

Yuwen Zhu | Zendy; Junkai Yan | Zendy; Juanjuan Li | Zendy; Yangming Ou | Zendy; Qing Yang | Zendy

Open Access

Knockdown of Radixin Suppresses Gastric Cancer Metastasis In Vitro by Up-Regulation of E-Cadherin via NF-κB/Snail Pathway

Author(s) -

Yuwen Zhu,

Junkai Yan,

Juanjuan Li,

Yangming Ou,

Qing Yang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000452518

Subject(s) - gene knockdown , radixin , moesin , microbiology and biotechnology , biology , cell adhesion , cadherin , cancer cell , cancer research , cancer , ezrin , cell culture , cell , cytoskeleton , biochemistry , genetics

Radixin has recently been shown to correlate with the metastasis of gastric cancer, but the pathogenesis is elusive. Adhesion proteins contribute to the regulation of metastasis, and thus this study sought to investigate the role of radixin in the migration, invasion and adhesion of gastric cancer cells, as well as its interaction with adhesion proteins in vitro.

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