Activation of Hepatic Stellate Cells is Inhibited by microRNA-378a-3p via Wnt10a | Zendy

Fujun Yu | Zendy; XuFei Fan | Zendy; Bicheng Chen | Zendy; Peihong Dong | Zendy; Jianjian Zheng | Zendy

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Activation of Hepatic Stellate Cells is Inhibited by microRNA-378a-3p via Wnt10a

Author(s) -

Fujun Yu,

XuFei Fan,

Bicheng Chen,

Peihong Dong,

Jianjian Zheng

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000452509

Subject(s) - wnt signaling pathway , hepatic stellate cell , gene silencing , microrna , fibrosis , cirrhosis , cancer research , biology , catenin , hepatic fibrosis , downregulation and upregulation , chemistry , microbiology and biotechnology , signal transduction , endocrinology , medicine , biochemistry , gene

Wnt/β-catenin pathway is involved in liver fibrosis and microRNAs (miRNAs) are considered as key regulators of the activation of hepatic stellate cells (HSCs). A recent study showed the protective role of miR-378a-3p against cardiac fibrosis. However, whether miR-378a-3p suppresses Wnt/β-catenin pathway in liver fibrosis is largely unknown.

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