Microbiota Plays a Key Role in Non-Steroidal Anti-Inflammatory Drug-Induced Small Intestinal Damage | Zendy

Koji Otani | Zendy; Tetsuya Tanigawa | Zendy; Toshio Watanabe | Zendy; Sunao Shimada | Zendy; Yuji Nadatani | Zendy; Yasuaki Nagami | Zendy; Fumio Tanaka | Zendy; Noriko Kamata | Zendy; Hirokazu Yamagami | Zendy; Masatsugu Shiba | Zendy; Kazunari Tominaga | Zendy; Yasuhiro Fujiwara | Zendy; Tetsuo Arakawa | Zendy

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Microbiota Plays a Key Role in Non-Steroidal Anti-Inflammatory Drug-Induced Small Intestinal Damage

Author(s) -

Koji Otani,

Tetsuya Tanigawa,

Toshio Watanabe,

Sunao Shimada,

Yuji Nadatani,

Yasuaki Nagami,

Fumio Tanaka,

Noriko Kamata,

Hirokazu Yamagami,

Masatsugu Shiba,

Kazunari Tominaga,

Yasuhiro Fujiwara,

Tetsuo Arakawa

Publication year - 2017

Publication title -

digestion

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.882

H-Index - 75

eISSN - 1421-9867

pISSN - 0012-2823

DOI - 10.1159/000452356

Subject(s) - inflammasome , proinflammatory cytokine , pyrin domain , dysbiosis , tlr4 , barrier function , intestinal permeability , lipopolysaccharide , tumor necrosis factor alpha , intestinal mucosa , medicine , pharmacology , gut flora , inflammation , immunology , biology , microbiology and biotechnology

Non-steroidal anti-inflammatory drugs (NSAIDs) damage the small intestine by causing multiple erosions and ulcers. However, to date, no established therapies and prophylactic agents are available to treat such damages. We reviewed the role of intestinal microbiota in NSAID-induced intestinal damage and identified potential therapeutic candidates.

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