Open AccessProtease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation
Author(s) -
Silvio Antoniak,
Jessica C. Cardenas,
Laura Buczek,
Frank Church,
Nigel Mackman,
Rafał Pawliński
Publication year - 2016
Publication title -
cardiology
Language(s) - English
Resource type - Journals
eISSN - 1421-9751
pISSN - 0008-6312
DOI - 10.1159/000452269
Subject(s) - angiotensin ii , medicine , endocrinology , inflammation , fibrosis , receptor , thrombin , chemistry , muscle hypertrophy , aorta , platelet
Angiotensin II (Ang II) plays an important role in cardiovascular disease. It also leads to the activation of coagulation. The coagulation protease thrombin induces cellular responses by activating protease-activated receptor 1 (PAR-1). We investigated whether PAR-1 contributes to Ang II-induced cardiovascular remodeling and inflammation.
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