Calcitriol Reduces Eosinophil Necrosis Which Leads to the Diminished Release of Cytotoxic Granules | Zendy

Caroline Ethier | Zendy; Yingqi Yu | Zendy; Lisa Cameron | Zendy; Paige Lacy | Zendy; Francis Davoine | Zendy

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Calcitriol Reduces Eosinophil Necrosis Which Leads to the Diminished Release of Cytotoxic Granules

Author(s) -

Caroline Ethier,

Yingqi Yu,

Lisa Cameron,

Paige Lacy,

Francis Davoine

Publication year - 2016

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000450951

Subject(s) - calcitriol , eosinophil , propidium iodide , endocrinology , immunology , medicine , biology , chemistry , vitamin d and neurology , apoptosis , biochemistry , programmed cell death , asthma

Asthma severity and eosinophilia correlate with a deficiency in vitamin D and its active metabolite calcitriol. Calcitriol modulates numerous leukocyte functions, but its effect on eosinophils is not fully understood. We postulated that calcitriol exerts a direct effect on eosinophil biology by modulating cell survival.

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