Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis | Zendy

Giovanni Almanzar | Zendy; Matthias Klein | Zendy; Marc Schmalzing | Zendy; Deborah Hilligardt | Zendy; Nady El Hajj | Zendy; Hermann Kneitz | Zendy; Vanessa Wild | Zendy; Andreas Rosenwald | Zendy; Sandrine Benoit | Zendy; Henning Hamm | Zendy; HansPeter Tony | Zendy; Thomas Haaf | Zendy; Matthias Goebeler | Zendy; Martina Prelog | Zendy

Open Access

Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis

Author(s) -

Giovanni Almanzar,

Matthias Klein,

Marc Schmalzing,

Deborah Hilligardt,

Nady El Hajj,

Hermann Kneitz,

Vanessa Wild,

Andreas Rosenwald,

Sandrine Benoit,

Henning Hamm,

HansPeter Tony,

Thomas Haaf,

Matthias Goebeler,

Martina Prelog

Publication year - 2016

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000450949

Subject(s) - foxp3 , immunology , rar related orphan receptor gamma , phenotype , pathogenesis , medicine , autoimmune disease , effector , inflammation , biology , immune system , gene , antibody , genetics

There is much evidence that T cells are strongly involved in the pathogenesis of localized and systemic forms of scleroderma (SSc). A dysbalance between FoxP3+ regulatory CD4+ T cells (Tregs) and inflammatory T-helper (Th) 17 cells has been suggested.

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