Gene-Environment Interaction in Parkinson's Disease: Coffee, ADORA2A, and CYP1A2 | Zendy

YuHsuan Chuang | Zendy; Christina M. Lill | Zendy; PeiChen Lee | Zendy; Johnni Hansen | Zendy; Christina Funch Lassen | Zendy; Lars Bertram | Zendy; Naomi Greene | Zendy; Janet S. Sinsheimer | Zendy; Beate Ritz | Zendy

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Gene-Environment Interaction in Parkinson's Disease: Coffee, ADORA2A, and CYP1A2

Author(s) -

YuHsuan Chuang,

Christina M. Lill,

PeiChen Lee,

Johnni Hansen,

Christina Funch Lassen,

Lars Bertram,

Naomi Greene,

Janet S. Sinsheimer,

Beate Ritz

Publication year - 2016

Publication title -

neuroepidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.217

H-Index - 87

eISSN - 1423-0208

pISSN - 0251-5350

DOI - 10.1159/000450855

Subject(s) - medicine , caffeine , endocrinology , cyp1a2 , population , metabolism , cytochrome p450 , environmental health

Drinking caffeinated coffee has been reported to provide protection against Parkinson's disease (PD). Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic neurotransmission and Cytochrome P450 1A2 (gene: CYP1A2) metabolizes caffeine; thus, gene polymorphisms in ADORA2A and CYP1A2 may influence the effect coffee consumption has on PD risk.

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