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Drinking caffeinated coffee has been reported to provide protection against Parkinson's disease (PD). Caffeine is an adenosine A2A receptor (encoded by the gene ADORA2A) antagonist that increases dopaminergic neurotransmission and Cytochrome P450 1A2 (gene: CYP1A2) metabolizes caffeine; thus, gene polymorphisms in ADORA2A and CYP1A2 may influence the effect coffee consumption has on PD risk.

neuroepidemiology

Gene-Environment Interaction in Parkinson's Disease: Coffee, &lt;b&gt;&lt;i&gt;ADORA2A&lt;/i&gt;&lt;/b&gt;, and &lt;b&gt;&lt;i&gt;CYP1A2&lt;/i&gt;&lt;/b&gt;