Hydrogen Sulfide and T-Type Ca2+ Channels in Pain Processing, Neuronal Differentiation and Neuroendocrine Secretion | Zendy

Kazuki Fukami | Zendy; Fumiko Sekiguchi | Zendy; Atsufumi Kawabata | Zendy

Open Access

Hydrogen Sulfide and T-Type Ca<sup>2+</sup> Channels in Pain Processing, Neuronal Differentiation and Neuroendocrine Secretion

Author(s) -

Kazuki Fukami,

Fumiko Sekiguchi,

Atsufumi Kawabata

Publication year - 2016

Publication title -

pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.51

H-Index - 59

eISSN - 1423-0313

pISSN - 0031-7012

DOI - 10.1159/000449449

Subject(s) - cystathionine beta synthase , chemistry , endocrinology , medicine , cysteine , microbiology and biotechnology , enzyme , biology , biochemistry

Hydrogen sulfide (H2S), a gasotransmitter, is generated from L-cysteine by mainly 3 enzymes, cystathionine-γ-lyase (CSE), cystathionine-β-synthase, and 3-mercaptopyruvate sulfurtransferase in cooperation with cysteine aminotransferase. The H2S-forming enzymes, particularly CSE, are overexpressed under the pathological conditions such as inflammation, neuronal or neuroendocrine differentiation and cancer development. Given that Cav3.2 T-type Ca2+ channels mediate some of the biological activity of H2S, we focus on the role of the H2S/Cav3.2 pathway in regulating the neuronal and neuroendocrine function.

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