Longitudinal Changes in Measured Glomerular Filtration Rate, Renal Fibrosis and Biomarkers in a Rat Model of Type 2 Diabetic Nephropathy | Zendy

Zhi Su | Zendy; D. L. Widomski | Zendy; Ji Ma | Zendy; Marian T. Namovic | Zendy; Arthur L. Nikkel | Zendy; Laura Leys | Zendy; L. Olson | Zendy; K. Salte | Zendy; Diana L. DonnellyRoberts | Zendy; Timothy A. Esbenshade | Zendy; Steve McGaraughty | Zendy

Open Access

Longitudinal Changes in Measured Glomerular Filtration Rate, Renal Fibrosis and Biomarkers in a Rat Model of Type 2 Diabetic Nephropathy

Author(s) -

Zhi Su,

D. L. Widomski,

Ji Ma,

Marian T. Namovic,

Arthur L. Nikkel,

Laura Leys,

L. Olson,

K. Salte,

Diana L. DonnellyRoberts,

Timothy A. Esbenshade,

Steve McGaraughty

Publication year - 2016

Publication title -

american journal of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 85

eISSN - 1421-9670

pISSN - 0250-8095

DOI - 10.1159/000449324

Subject(s) - medicine , renal function , endocrinology , fibrosis , proteinuria , nephropathy , kidney , diabetic nephropathy , diabetes mellitus

Obese ZSF-1 rats display many features of human type II diabetes including nephropathy (DN). The study aimed to further understand the relevance of this model to DN, for which glomerular filtration rate (GFR), renal fibrosis and several urinary/tissue biomarkers was followed over 24 weeks in ZSF-1 rats.

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