Injection of hTERT-Transduced Endothelial Progenitor Cells Promotes Beneficial Aortic Changes in a High-Fat Dietary Model of Early Atherosclerosis | Zendy

Xingsheng Li | Zendy; Yanru Deng | Zendy; Shunrong Zhao | Zendy; Dandan Zhang | Zendy; Qingwei Chen | Zendy

Open Access

Injection of hTERT-Transduced Endothelial Progenitor Cells Promotes Beneficial Aortic Changes in a High-Fat Dietary Model of Early Atherosclerosis

Author(s) -

Xingsheng Li,

Yanru Deng,

Shunrong Zhao,

Dandan Zhang,

Qingwei Chen

Publication year - 2016

Publication title -

cardiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.547

H-Index - 63

eISSN - 1421-9751

pISSN - 0008-6312

DOI - 10.1159/000447997

Subject(s) - telomerase reverse transcriptase , enos , progenitor cell , endothelial progenitor cell , telomerase , cd44 , medicine , stem cell , endocrinology , immunology , cancer research , nitric oxide , chemistry , biology , in vitro , nitric oxide synthase , microbiology and biotechnology , biochemistry , gene

Cultured endothelial progenitor cells (EPCs) display troubling issues that adversely affect their applicability to endothelial regeneration. We hypothesized that transduction of the human telomerase catalytic subunit (hTERT) gene would enhance EPC function in treating dietary-induced early atherosclerosis (AS).

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