Inhibition of ERK1/2 Signaling Pathway is Involved in Melatonin's Antiproliferative Effect on Human MG-63 Osteosarcoma Cells | Zendy

Lifeng Liu | Zendy; Ying Xu | Zendy; Russel J. Reıter | Zendy; Yutao Pan | Zendy; Di Chen | Zendy; Yangzhou Liu | Zendy; Xingyu Pu | Zendy; Li-Guo Jiang | Zendy; Zengchun Li | Zendy

Open Access

Inhibition of ERK1/2 Signaling Pathway is Involved in Melatonin's Antiproliferative Effect on Human MG-63 Osteosarcoma Cells

Author(s) -

Lifeng Liu,

Ying Xu,

Russel J. Reıter,

Yutao Pan,

Di Chen,

Yangzhou Liu,

Xingyu Pu,

Li-Guo Jiang,

Zengchun Li

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447922

Subject(s) - melatonin , protein kinase b , cyclin d1 , mapk/erk pathway , cyclin dependent kinase 1 , propidium iodide , cell cycle , signal transduction , cyclin b1 , biology , pi3k/akt/mtor pathway , p38 mitogen activated protein kinases , cancer research , chemistry , microbiology and biotechnology , medicine , endocrinology , cell , apoptosis , biochemistry , programmed cell death

In a previous study, we found that melatonin inhibits MG-63 osteosarcoma cell proliferation; however, the underlying mechanisms remain elusive. Mitogen-activated protein kinase (MAPK) and Akt signaling pathways play key roles in the anticancer effects of melatonin.

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