Inhibition of Cartilage Acidic Protein 1 Reduces Ultraviolet B Irradiation Induced-Apoptosis through P38 Mitogen-Activated Protein Kinase and Jun Amino-Terminal Kinase Pathways | Zendy

Yinghong Ji | Zendy; Xianfang Rong | Zendy; Dan Li | Zendy; Lei Cai | Zendy; Jun Rao | Zendy; Yi Lü | Zendy

Open Access

Inhibition of Cartilage Acidic Protein 1 Reduces Ultraviolet B Irradiation Induced-Apoptosis through P38 Mitogen-Activated Protein Kinase and Jun Amino-Terminal Kinase Pathways

Author(s) -

Yinghong Ji,

Xianfang Rong,

Dan Li,

Lei Cai,

Jun Rao,

Yi Lü

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447920

Subject(s) - p38 mitogen activated protein kinases , apoptosis , reactive oxygen species , kinase , oxidative stress , superoxide dismutase , microbiology and biotechnology , western blot , protein kinase a , malondialdehyde , chemistry , signal transduction , biology , biochemistry , gene

Ultraviolet B (UVB) irradiation can easily induce apoptosis in human lens epithelial cells (HLECs) and further lead to various eye diseases including cataract. Here for the first time, we investigated the role of cartilage acidic protein 1 (CRTAC1) gene in UVB irradiation induced-apoptosis in HLECs.

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