Autophagy Prevents Oxidative Stress-Induced Loss of Self-Renewal Capacity and Stemness in Human Tendon Stem Cells by Reducing ROS Accumulation | Zendy

Hua Chen | Zendy; Heng’an Ge | Zendy; Gen-bing Wu | Zendy; Biao Cheng | Zendy; Yong Lü | Zendy; Chaoyin Jiang | Zendy

Open Access

Autophagy Prevents Oxidative Stress-Induced Loss of Self-Renewal Capacity and Stemness in Human Tendon Stem Cells by Reducing ROS Accumulation

Author(s) -

Hua Chen,

Heng’an Ge,

Gen-bing Wu,

Biao Cheng,

Yong Lü,

Chaoyin Jiang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447916

Subject(s) - microbiology and biotechnology , autophagy , oxidative stress , stem cell , gene silencing , chemistry , small hairpin rna , biology , apoptosis , biochemistry , gene knockdown , gene

Tendon stem cells (TSCs) exhibit a high self-renewal capacity, multi-differentiation potential, and low immunogenicity; thus, these cells might provide a new cell source for tendon repair and regeneration. TSCs are exposed to increased oxidative stress at tendon injury sites; however, how TSCs maintain their stemness under oxidative stress is not clear.

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