Kappa-Opioid Agonist U50,488H-Mediated Protection Against Heart Failure Following Myocardial Ischemia/Reperfusion: Dual Roles of Heme Oxygenase-1 | Zendy

Guang Tong | Zendy; Ben Zhang | Zendy; Xuan Zhou | Zendy; Jinbo Zhao | Zendy; Zhongchan Sun | Zendy; Ye Tao | Zendy; Jianming Pei | Zendy; Weida Zhang | Zendy

Open Access

Kappa-Opioid Agonist U50,488H-Mediated Protection Against Heart Failure Following Myocardial Ischemia/Reperfusion: Dual Roles of Heme Oxygenase-1

Author(s) -

Guang Tong,

Ben Zhang,

Xuan Zhou,

Jinbo Zhao,

Zhongchan Sun,

Ye Tao,

Jianming Pei,

Weida Zhang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447911

Subject(s) - heme oxygenase , cardioprotection , protein kinase b , pharmacology , medicine , oxidative stress , downregulation and upregulation , cardiac function curve , reperfusion injury , agonist , chemistry , heart failure , ischemia , endocrinology , heme , phosphorylation , receptor , biochemistry , gene , enzyme

The selective κ-opioid agonist U50,488H protects heart from myocardial ischemia-reperfusion (MI/R) injury. We examined whether U50,488H is also beneficial for MI/R induced heart failure.

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