Triggering of Suicidal Erythrocyte Death by Fascaplysin | Zendy

Morena Mischitelli | Zendy; Mohamed Jèmaà | Zendy; Mustafa Almasry | Zendy; Caterina Faggio | Zendy; Florian Läng | Zendy

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Triggering of Suicidal Erythrocyte Death by Fascaplysin

Author(s) -

Morena Mischitelli,

Mohamed Jèmaà,

Mustafa Almasry,

Caterina Faggio,

Florian Läng

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447865

Subject(s) - phosphatidylserine , ceramide , chemistry , apoptosis , cytosol , oxidative stress , annexin , flow cytometry , sphingomyelin , hemoglobin , cell , extracellular , biophysics , intracellular , reactive oxygen species , fluorescence , biochemistry , membrane , phospholipid , microbiology and biotechnology , biology , enzyme , physics , quantum mechanics

The bis-indole alkaloid Fascaplysin is effective against malignancy, an effect at least partially due to stimulation of tumor cell apoptosis. Similar to apoptosis of nucleated cells, erythrocytes could enter suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Triggers of eryptosis include increase of cytosolic Ca2+ activity ([Ca2+]i), oxidative stress and ceramide. The present study explored, whether Fascaplysin induces eryptosis and, if so, to shed light on the cellular mechanisms involved.

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