Ca2+ Entry, Oxidative Stress, Ceramide and Suicidal Erythrocyte Death Following Diosgenin Treatment | Zendy

Morena Mischitelli | Zendy; Mohamed Jèmaà | Zendy; Mustafa Almasry | Zendy; Caterina Faggio | Zendy; Florian Läng | Zendy

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Ca2+ Entry, Oxidative Stress, Ceramide and Suicidal Erythrocyte Death Following Diosgenin Treatment

Author(s) -

Morena Mischitelli,

Mohamed Jèmaà,

Mustafa Almasry,

Caterina Faggio,

Florian Läng

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447864

Subject(s) - phosphatidylserine , ceramide , diosgenin , oxidative stress , apoptosis , microbiology and biotechnology , chemistry , annexin , cytosol , reactive oxygen species , sphingomyelin , biology , biochemistry , biophysics , phospholipid , membrane , organic chemistry , enzyme

The bioactive steroid sapogenin diosgenin is considered for a wide variety of applications including treatment of malignancy. The substance counteracts tumor growth in part by stimulating apoptosis of tumor cells. Similar to apoptosis of nucleated cells, erythrocytes may enter suicidal death or eryptosis, which is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Signaling involved in the stimulation of eryptosis includes increase of cytosolic Ca2+ activity ([Ca2+]i), oxidative stress and ceramide. The present study explored, whether diosgenin induces eryptosis and, if so, to decipher cellular mechanisms involved.

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