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Alterations in Cardiomyocyte Differentiation-Related Proteins in Rat Mesenchymal Stem Cells Exposed to Hypoxia
Author(s) -
JungWon Choi,
Kyung-Eun Kim,
Chang Youn Lee,
Jiyun Lee,
HyangHee Seo,
Kyu Hee Lim,
Eunhyun Choi,
Soyeon Lim,
Seahyong Lee,
Sang Woo Kim,
KiChul Hwang
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000447861
Subject(s) - mesenchymal stem cell , hypoxia (environmental) , microbiology and biotechnology , stem cell , biology , cellular differentiation , chemistry , biochemistry , gene , organic chemistry , oxygen
It is known that mesenchymal stem cells (MSCs) can have variable responses to hypoxic conditions and that hypoxia may specifically stimulate differentiation into osteogenic, chondrogenic, or adipogenic cells. Based on our previous study, we hypothesized that hypoxia may also induce MSC differentiation into cardiomyocytes and/or cells with comparable phenotypes.

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