Open AccessTau Tubulin Kinase TTBK2 Sensitivity of Glutamate Receptor GluK2
Author(s) -
Kristiieding,
Veronika Matschke,
Sven G. Meuth,
Florian Läng,
Guiscard Seebohm,
Nathalie StrutzSeebohm
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000447847
Subject(s) - microbiology and biotechnology , biology , glutamate receptor , chemistry , biochemistry , receptor
Inherited, autosomal dominant spinocerebellar ataxia type 11 (SCA11) is caused by loss of function mutations of TTBK2 (tau tubulin kinase 2). Mutations observed in patients with SCA11 include truncated TTBK2(450). The present study explored the possibility that TTBK2 influences the function of the glutamate receptor GluK2.
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