Silencing of Long Non-Coding RNA NONHSAT009968 Ameliorates the Staphylococcal Protein A-Inhibited Osteogenic Differentiation in Human Bone Mesenchymal Stem Cells | Zendy

Yi Cui | Zendy; Sheng Lü | Zendy; Hongbo Tan | Zendy; Jun Li | Zendy; Min Zhu | Zendy; Yongqing Xu | Zendy

Open Access

Silencing of Long Non-Coding RNA NONHSAT009968 Ameliorates the Staphylococcal Protein A-Inhibited Osteogenic Differentiation in Human Bone Mesenchymal Stem Cells

Author(s) -

Yi Cui,

Sheng Lü,

Hongbo Tan,

Jun Li,

Min Zhu,

Yongqing Xu

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447839

Subject(s) - mesenchymal stem cell , runx2 , alkaline phosphatase , chemistry , osteoblast , proinflammatory cytokine , stem cell , microbiology and biotechnology , inflammation , biology , immunology , in vitro , biochemistry , enzyme

Osteomyelitis is defined as an inflammation of the bones and bone marrow. The inflammatory microenvironment attenuates the osteogenic differentiation capacity of stem cells and inhibits osteoblast-mediated bone formation, leading to net bone loss. However, the whole expression profile, function and side effect of long non-coding RNAs (lncRNAs) on osteogenic differentiation of stem cells in an inflammatory microenvironment of osteomyelitis are not known.

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